The U.S. Food and Drug Administration (FDA) approved Eli Lilly and Company’s Zepbound™ (tirzepatide) injection, the first and only obesity treatment of its kind that activates both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors. This article provides you with a comprehensive review of this new drug Zepbound, look no further. Don’t miss out on this game-changing weight loss solution – read our review now!
Zepbound is a dual agonist of two gut hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones work in a number of ways to promote weight loss, including:
- Reducing appetite and hunger
- Increasing satiety (feeling of fullness)
- Slowing down gastric emptying (the rate at which food leaves the stomach)
- Increasing insulin secretion and reducing glucagon secretion (which helps to lower blood sugar levels)
- Increasing calorie burning
How is Zepbound different from the other FDA-approved GLP-1s for weight loss?
Zepbound is a combination drug. It is the only FDA-approved weight loss drug that combines GLP-1 and GIP agonism. Other FDA-approved GLP-1 agonists for weight loss include semaglutide (Ozempic and Wegovy) and dulaglutide (Trulicity).
How much weight can I lose with Zepbound?
In clinical trials, Zepbound was shown to be more effective than semaglutide for weight loss.
In SURMOUNT-1, a study involving more than 2,500 adults, people taking Zepbound as an adjunct to diet and exercise experienced substantial weight loss compared with placebo at 72 weeks. At the highest dose (15 mg), people taking Zepbound lost on average 48 lb., while at the lowest dose (5 mg), people lost on average 34 lb. (compared to 7 lb. on placebo). Additionally, 1 in 3 patients taking Zepbound at the highest dose lost over 58 lb. (25% of body weight), compared to 1.5% on placebo.
In a study of over 2,500 people with obesity, Zepbound led to an average weight loss of 18.9%, compared to 15.1% with semaglutide. Zepbound was also more effective than dulaglutide for weight loss in another clinical trial.
What is the difference between Mounjaro and Zepbound?
Mounjaro and Zepbound are the same drug. Mounjaro is approved for the treatment of type 2 diabetes, while Zepbound is approved for weight loss.
Who is Zepbound recommended for? Are there people who should not use it? Why?
Zepbound is recommended for adults with a body mass index (BMI) of at least 30, or a BMI of at least 27 with at least one weight-related condition such as type 2 diabetes, high blood pressure, or high cholesterol.
People who should not use Zepbound include:
- People with a history of pancreatitis or medullary thyroid cancer
- People who are allergic to any of the ingredients in Zepbound
- Pregnant or breastfeeding women
What's the cost difference between Zepbound and Ozempic/Wegovy/Mounjaro?
The cost of Zepbound is comparable to the cost of other GLP-1 agonists for weight loss. The exact cost will vary depending on your insurance coverage.
Competition could also result in lower net prices for both drugs or how much payers actually spend on them. The prices are high for Wegovy — with a list price of up to $1,349 every four weeks and a net price of around $700. Zepbound is starting with a list price of around $1,060, according to Eli Lilly.
Will insurance cover it for weight loss?
Some insurance plans may cover Zepbound for weight loss. However, there is a lot of variation from plan to plan. It is important to check with your insurance company to see if they cover Zepbound and what your out-of-pocket costs will be. Our team at Valley Forge Weight Management Center will work with your insurance company to complete all necessary paperwork.
How can I get a Zepbound prescription?
Zepbound is indicated for adults with obesity (with a BMI of 30 kg/m2 or greater), or those who are overweight (with a BMI of 27 kg/m2 or greater) and also have weight-related medical problems such as hypertension, dyslipidemia, type 2 diabetes mellitus, obstructive sleep apnea or cardiovascular disease, to lose weight and keep it off. Talk to your doctor about whether Zepbound is the right medication for you.
Can I get a Zepbound prescription near me?
Zepbound will be available in the US by the end of year 2023. If you live in the state of New Jersey or Pennsylvania, please contact us today. We will discuss with you various weight loss medication options including Tirzepatide. You can text us, call us, or Schedule a Free Consultation with a physician to discuss your options.